Transcriptional activity of GR and NF-κB signaling pathways. TELiS bioinformatics analysis assessed trans-activational activity based on the relative prevalence of GR and NF-κB response elements in the promoters of all 209 transcripts over-expressed in high- versus low-lonely individuals (data represent mean ± standard error prevalence of response elements within promoters from each group). Contributions of in-trans regulatory influences to the observed inverse skew of NF-κB and GR response elements within differentially expressing promoters was tested by comparison to a null distribution of genome-wide DNA cis-structural associations generated by 10,000 random samples of 209 transcripts assayed by Affymetrix U133A arrays.
Cole et al. Genome Biology 2007 8:R189 doi:10.1186/gb-2007-8-9-r189