Table 3

Transcription factor-binding motifs in promoters of loneliness-related genes

TFBM

Low lonely

High lonely

Ratio

t

df

p


V$CEBP_Q2 (C/EBP)

0.714

0.340

0.476

-2.76

120.3

0.0067

V$OCT1_03 (Oct)

1.400

0.793

0.566

-2.60

115.7

0.0106

V$CREL_01 (NF-κB)

0.129

0.377

2.935

2.62

74.6

0.0108

V$GATA1_03 (GATA)

0.557

0.245

0.440

-2.52

120.2

0.0131

V$OCT1_04 (Oct)

0.086

0.000

0.000

-2.54

69.0

0.0132

V$OCT_C (Oct)

0.071

0.000

0.000

-2.30

69.0

0.0242

V$AHRARNT_01 (AHR)

0.043

0.208

4.843

2.28

65.4

0.0258

V$BARBIE_01 (BARBIE)

0.043

0.208

4.843

2.28

65.4

0.0258

V$GR_Q6 (GRE)

0.257

0.094

0.367

-2.17

112.1

0.0325

V$STAT_01 (STAT)

0.014

0.151

10.566

2.13

57.4

0.0376

V$TAL1BETAE47_01

0.057

0.000

0.000

-2.04

69.0

0.0447

V$TAL1ALPHAE47_01

0.057

0.000

0.000

-2.04

69.0

0.0447

V$IRF1_01 (IRF1)

0.086

0.000

0.000

-1.93

69.0

0.0572


TFBM: transcription factor-binding motif (V$ = TRANSFAC Vertebrate). Low lonely: average TFBM prevalence in promoters of genes up-regulated in low-lonely. High lonely: average TFBM prevalence in promoters of genes up-regulated in high-lonely. Ratio: high-lonely/low-lonely. t Statistic: Welch formula for unequal variances. df: continuous degrees of freedom for Welch unequal variance t-test. p value: two-tailed.

Cole et al. Genome Biology 2007 8:R189   doi:10.1186/gb-2007-8-9-r189

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