Open Access Software

DetectiV: visualization, normalization and significance testing for pathogen-detection microarray data

Michael Watson1*, Juliet Dukes2, Abu-Bakr Abu-Median1, Donald P King2 and Paul Britton1

Author Affiliations

1 Institute for Animal Health, Compton, Newbury, Berks RG20 7NN, UK

2 Institute for Animal Health, Pirbright, Surrey GU24 0NF, UK

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Genome Biology 2007, 8:R190 doi:10.1186/gb-2007-8-9-r190

Published: 14 September 2007

Abstract

DNA microarrays offer the possibility of testing for the presence of thousands of micro-organisms in a single experiment. However, there is a lack of reliable bioinformatics tools for the analysis of such data. We have developed DetectiV, a package for the statistical software R. DetectiV offers powerful yet simple visualization, normalization and significance testing tools. We show that DetectiV performs better than previously published software on a large, publicly available dataset.