Model of interaction effects. Upon close cell-cell contact the tumor cells (red) interact with the fibroblasts (yellow) (1), which express type I interferon (IFNα and IFNβ) (2). They in turn induce the interferon response genes predominantly in the tumor cells (3).
Buess et al. Genome Biology 2007 8:R191 doi:10.1186/gb-2007-8-9-r191