Figure 1.

Comparison of host gene expression profiles following infection with different pathogens. Expression levels are indicated by a color scale and represent normalized differences between infected and control animals. Grey denotes genes not considered to be differentially regulated under that condition. The numbers on the vertical axis correspond to differentially regulated genes. Each column shows the expression levels of individual genes (represented as rows) following infection by the pathogens as indicated on the horizontal axis (S. m, S. marcescens; E. f, E. faecalis; E. c, E. carotovora; P. l, P. luminescens). (a) Genes differentially regulated in an infection with P. luminescens and their comparative expression levels with other pathogens. (b) Genes defining a pathogen-specific signature specifically up-regulated with P. luminescens infection. (c) Groupings, as indicated by the horizontal bars, formed after clustering using non-redundant sets of genes that were up- and down-regulated by at least two pathogens (trees not shown). (d) Genes commonly up-regulated following E. carotovora, E. faecalis and P. luminescens infections.