Modeling the molecular basis underlying an intestine-localized, pathogen-shared response to infection in C. elegans. Three major components make up the model; the common response genes identified directly in this study, genes associated with common response genes on the basis of shared DNA motifs, and interactors of the common response genes, either genetic (Wormbase) or physical (core or scaffold; InteractomeDB). Unambiguous evidence for expression in the intestine exists for all indicated genes. The relevant biological functions are shown in different colors.
Wong et al. Genome Biology 2007 8:R194 doi:10.1186/gb-2007-8-9-r194