Table 1

RFX target genes in C. elegans and D. melanogaster and in compartmentalized ciliogenesis

D. melanogaster gene ID (name)

Homologs in vertebrates or Chlamydomonas

Fold variation

Ciliary type [13]

C. elegans gene ID (name)

DAF-19 control in C. elegans


Downregulated >2 fold

CG1126

BBS5

95.2*

Cp

R01H10.6 (bbs-5)

All [14]

CG3769

D2LIC/LIC3

63*

-

F02D8.3 (xbx-1)

All [21,35]

CG4525

Novel

223.6*

Cp

C27H5.7 (dyf-13)

All [37]

CG8853

IFT55/hippi

21.8*

Cp

F59C6.7 (che-13)

All [33]

CG9333 (oseg5)

WDR56

4.4*

Cp

F38G1.1 (che-2)

All [21]

CG9595 (osm-6)

NDG5

22.2*

Cp

R31.3 (osm-6)

All [21]

CG12548 (nompB)

TG737

12.7 [92]*

Cp

Y41g9a.1 (osm-5)

All [34]

CG13691 (BBS8)

BBS8

2.7*

Cp

T25F10.5 (bbs-8)

All [36]

CG13809 (oseg2)

IFT172/wim

9.7*in vivo

Cp

T27B1.1 (osm-1)

All [21]

CG14825 (BBS1)

BBS1

211*

Cp

Y105E8A.5 (bbs-1)

All [36,37]

CG15666

BBS9

20*

-

C48B6.8

All [37]

CG17599

QILIN

29.5*

Cp

C04C3.5 (dyf-3)

All [93]

CG9398 (Tulp)

Tubby

3.2

-

F10B5.4 (tub-1)

Subset [36]

CG3259

Traf3ip1/MIP-T3

In vivo

Cp

C02H7.1

ND

CG5142

Novel

16.4*

Cp

F54C1.5a (dyf-1)

ND

CG7735

BBS3

40.9*

Cp

C38D4.8 (arl-6)

ND

CG9227 (tectonic)

tectonic

In vivo

Cp

Y38F2AL.2

ND

CG14367

Novel

10.2

Cp

Y108G3AL.3

ND

CG14870

B9 domain

3.1*

Cp

K03E6.4

ND

CG15161

IFT46

207.1*

Cp

F46F6.4 (dyf-6)

ND

CG18631

Novel

14.2*

Cp

K07G5.3

ND

CG13232 (BBS4)

BBS4

17*

-

-

-

Downregulated <2-fold

CG30441

IFT20

2

Cp

Y110A7A.20

All [37]

CG1399-PB

LRRC16

1.8

Cp

K07G5.1

ND

CG11048

Rib74

1.5

Cp

Y49A10A.1

ND

CG13178

Novel

1.7

Cp

R10F2.5

ND

Overexpressed

CG2006

Dtwd1

0.5*

Cp

Y53C12A.3

Invariant in Drosophila

CG5359

Tctex

1

D1009.5 (xbx-2/dylt-2)

All [36]

CG11237 (oseg6)

wdr19

1

Cp

ZK520.3 (dyf-2)

Subset [94]

CG6504 (amo)

PKD2

0.9

Y73F8A.1 (pkd-2)

Subset [95]

CG9710 (nudC)

NudC

0.7

F53A2.4 (nud-1)

Subset [36]

CG11838 (oseg3)

IFT140

1.4

Cp

C27A7.4 (che-11)

Subset [36]

CG2069 (oseg4)

WDR35

1

Cp

C54G7.4 (ifta-1)

ND

CG6560

arl3

1

Cp

F19H8.3 (arl-3)

ND

CG7161 (oseg1)

IFT122

1.4 in vivo

Cp

F23B2.4 (daf-10/osm-4)

ND

CG10642 (Klp64D)

KIF3A

1.1

Cp

Y50D7A.6 (klp-20)

ND

CG11755

Novel

1.1

Cp

D2089.3

ND

CG11759 (Kap3)

KIFAP3

1

Cp

F08F8.3 (kap-1)

ND

CG5195

L domain like

1.2

Cp

-

-

CG31249

Novel

0.9

Cp

-

-

CG32392

rshl2

1.1

Cp

-

-

Not determined in Drosophila

CG3798 (Nmda1)

ND

F40F9.1 (xbx-6)

Subset [36]

CG9310 (Hnf4)

HNF4A/G

ND

T19A5.4 (nhr-44)

Subset [36]

CG17228 (pros)

PROX1/2

ND

K12H4.1 (ceh-26)

Subset [95]

Not conserved in Drosophila

-

-

Y75B8A.12 (osm-12/bbs-7)

All [36]

-

-

F20D12.3 (bbs-2)

All [36]

-

-

M28.7 (nph-1)

All [96]

-

-

R13H4.1 (nph-4)

All [96]

-

-

C47E8.6

All [37]

-

-

ZK328.7a

All [37]

-

-

Y102E9.1 (odr-4)

Subset [36]

-

-

C23H5.3 (xbx-4)

Subset [36]

-

-

M04D8.6 (xbx-3)

Subset [36]

-

-

T24A11.2 (xbx-5)

Subset [36]

-

-

R148.1 (xbx-7)

Subset [36]

-

-

D2005.2 (nlp-8)

Subset [95]


*p value < 0.001; 0.001 <p value < 0.05; 0.05 <p value < 0.08. Dashes indicate not applicable. Cp, compartmentalized ciliogenesis; ND, not determined.

Laurençon et al. Genome Biology 2007 8:R195   doi:10.1186/gb-2007-8-9-r195

Open Data