Table 1 |
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|
RFX target genes in C. elegans and D. melanogaster and in compartmentalized ciliogenesis |
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| D. melanogaster gene ID (name) |
Homologs in vertebrates or Chlamydomonas |
Fold variation |
Ciliary type [13] |
C. elegans gene ID (name) |
DAF-19 control in C. elegans |
|
|
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| Downregulated >2 fold |
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| CG1126 |
BBS5 |
95.2* |
Cp |
R01H10.6 (bbs-5) |
All [14] |
| CG3769 |
D2LIC/LIC3 |
63* |
- |
F02D8.3 (xbx-1) |
All [21,35] |
| CG4525 |
Novel |
223.6* |
Cp |
C27H5.7 (dyf-13) |
All [37] |
| CG8853 |
IFT55/hippi |
21.8* |
Cp |
F59C6.7 (che-13) |
All [33] |
| CG9333 (oseg5) |
WDR56 |
4.4* |
Cp |
F38G1.1 (che-2) |
All [21] |
| CG9595 (osm-6) |
NDG5 |
22.2* |
Cp |
R31.3 (osm-6) |
All [21] |
| CG12548 (nompB) |
TG737 |
12.7 [92]* |
Cp |
Y41g9a.1 (osm-5) |
All [34] |
| CG13691 (BBS8) |
BBS8 |
2.7* |
Cp |
T25F10.5 (bbs-8) |
All [36] |
| CG13809 (oseg2) |
IFT172/wim |
9.7*in vivo |
Cp |
T27B1.1 (osm-1) |
All [21] |
| CG14825 (BBS1) |
BBS1 |
211* |
Cp |
Y105E8A.5 (bbs-1) |
All [36,37] |
| CG15666 |
BBS9 |
20* |
- |
C48B6.8 |
All [37] |
| CG17599 |
QILIN |
29.5* |
Cp |
C04C3.5 (dyf-3) |
All [93] |
| CG9398 (Tulp) |
Tubby |
3.2‡ |
- |
F10B5.4 (tub-1) |
Subset [36] |
| CG3259 |
Traf3ip1/MIP-T3 |
In vivo |
Cp |
C02H7.1 |
ND |
| CG5142 |
Novel |
16.4* |
Cp |
F54C1.5a (dyf-1) |
ND |
| CG7735 |
BBS3 |
40.9* |
Cp |
C38D4.8 (arl-6) |
ND |
| CG9227 (tectonic) |
tectonic |
In vivo |
Cp |
Y38F2AL.2 |
ND |
| CG14367 |
Novel |
10.2† |
Cp |
Y108G3AL.3 |
ND |
| CG14870 |
B9 domain |
3.1* |
Cp |
K03E6.4 |
ND |
| CG15161 |
IFT46 |
207.1* |
Cp |
F46F6.4 (dyf-6) |
ND |
| CG18631 |
Novel |
14.2* |
Cp |
K07G5.3 |
ND |
| CG13232 (BBS4) |
BBS4 |
17* |
- |
- |
- |
| Downregulated <2-fold |
|||||
| CG30441 |
IFT20 |
2‡ |
Cp |
Y110A7A.20 |
All [37] |
| CG1399-PB |
LRRC16 |
1.8† |
Cp |
K07G5.1 |
ND |
| CG11048 |
Rib74 |
1.5† |
Cp |
Y49A10A.1 |
ND |
| CG13178 |
Novel |
1.7† |
Cp |
R10F2.5 |
ND |
| Overexpressed |
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| CG2006 |
Dtwd1 |
0.5* |
Cp |
Y53C12A.3 |
|
| Invariant in Drosophila |
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| CG5359 |
Tctex |
1 |
D1009.5 (xbx-2/dylt-2) |
All [36] |
|
| CG11237 (oseg6) |
wdr19 |
1 |
Cp |
ZK520.3 (dyf-2) |
Subset [94] |
| CG6504 (amo) |
PKD2 |
0.9 |
Y73F8A.1 (pkd-2) |
Subset [95] |
|
| CG9710 (nudC) |
NudC |
0.7 |
F53A2.4 (nud-1) |
Subset [36] |
|
| CG11838 (oseg3) |
IFT140 |
1.4 |
Cp |
C27A7.4 (che-11) |
Subset [36] |
| CG2069 (oseg4) |
WDR35 |
1 |
Cp |
C54G7.4 (ifta-1) |
ND |
| CG6560 |
arl3 |
1 |
Cp |
F19H8.3 (arl-3) |
ND |
| CG7161 (oseg1) |
IFT122 |
1.4 in vivo |
Cp |
F23B2.4 (daf-10/osm-4) |
ND |
| CG10642 (Klp64D) |
KIF3A |
1.1 |
Cp |
Y50D7A.6 (klp-20) |
ND |
| CG11755 |
Novel |
1.1 |
Cp |
D2089.3 |
ND |
| CG11759 (Kap3) |
KIFAP3 |
1 |
Cp |
F08F8.3 (kap-1) |
ND |
| CG5195 |
L domain like |
1.2 |
Cp |
- |
- |
| CG31249 |
Novel |
0.9 |
Cp |
- |
- |
| CG32392 |
rshl2 |
1.1 |
Cp |
- |
- |
| Not determined in Drosophila |
|||||
| CG3798 (Nmda1) |
ND |
F40F9.1 (xbx-6) |
Subset [36] |
||
| CG9310 (Hnf4) |
HNF4A/G |
ND |
T19A5.4 (nhr-44) |
Subset [36] |
|
| CG17228 (pros) |
PROX1/2 |
ND |
K12H4.1 (ceh-26) |
Subset [95] |
|
| Not conserved in Drosophila |
|||||
| - |
- |
Y75B8A.12 (osm-12/bbs-7) |
All [36] |
||
| - |
- |
F20D12.3 (bbs-2) |
All [36] |
||
| - |
- |
M28.7 (nph-1) |
All [96] |
||
| - |
- |
R13H4.1 (nph-4) |
All [96] |
||
| - |
- |
C47E8.6 |
All [37] |
||
| - |
- |
ZK328.7a |
All [37] |
||
| - |
- |
Y102E9.1 (odr-4) |
Subset [36] |
||
| - |
- |
C23H5.3 (xbx-4) |
Subset [36] |
||
| - |
- |
M04D8.6 (xbx-3) |
Subset [36] |
||
| - |
- |
T24A11.2 (xbx-5) |
Subset [36] |
||
| - |
- |
R148.1 (xbx-7) |
Subset [36] |
||
| - |
- |
D2005.2 (nlp-8) |
Subset [95] |
||
|
|
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|
*p value < 0.001; †0.001 <p value < 0.05; ‡0.05 <p value < 0.08. Dashes indicate not applicable. Cp, compartmentalized ciliogenesis; ND, not determined. |
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|
Laurençon et al. Genome Biology 2007 8:R195 doi:10.1186/gb-2007-8-9-r195 |
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