Table 1

Effects of dietary cholesterol on plasma lipids and inflammation markers

Con

LC

HC


Body weight (start) (g)

20.3 ± 1.5

20.8 ± 1.5

20.6 ± 0.9

Body weight gain (g)

0.4 ± 0.7

0.7 ± 0.8

0.6 ± 0.5

Food intake (g/day)

2.6 ± 0.2

2.9 ± 0.3*

2.5 ± 0.2

Plasma cholesterol (mM)

5.9 ± 0.3

13.3 ± 1.9*

17.9 ± 2.4*

Plasma triglyceride (mM)

1.7 ± 0.4

2.3 ± 0.3

2.1 ± 0.7

Plasma E-selectin (μg/ml)

44.3 ± 2.3

44.3 ± 6.3

55.1 ± 8.5*

Plasma SAA (μg/ml)

2.8 ± 0.6

4.7 ± 1.7

8.3 ± 2.7*

Plasma ALAT (U/mL)

48 ± 44

45 ± 22

75 ± 23

Plasma ASAT (U/mL)

260 ± 123

237 ± 57

569 ± 221*


Three groups of female E3L mice were fed either a cholesterol-free (Con) diet or the same diet supplemented with 0.25% (LC) or 1.0% (HC) w/w cholesterol. Listed are the average body weight at the start (t = 0) of the experimental period together with the body weight gain, the average daily food intake and the average plasma levels of cholesterol, triglycerides, E-selectin, serum amyloid A (SAA), alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT). All data are mean ± standard deviation. *P < 0.05 versus Con; P < 0.05 versus LC (ANOVA, least significant difference post hoc test).

Kleemann et al. Genome Biology 2007 8:R200   doi:10.1186/gb-2007-8-9-r200

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