Table 2 |
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|
Overview of genes that are differentially expressed in response to cholesterol |
||||||
|
LC |
HC |
|||||
|
|
|
|||||
|
GO category |
Up |
Down |
Total |
Up |
Down |
Total |
|
|
||||||
|
Lipid and lipoprotein metabolism (includes cholesterol and steroid metabolism) |
8 |
50 |
58 |
37 |
114 |
151 |
|
Protein metabolism (includes protein folding and breakdown) |
34 |
14 |
48 |
143 |
98 |
241 |
|
Other metabolism (includes carbohydrate metabolism) |
32 |
19 |
51 |
122 |
130 |
252 |
|
Generation of precursor metabolites and energy |
10 |
15 |
25 |
24 |
47 |
71 |
|
Transport |
31 |
15 |
46 |
125 |
77 |
202 |
|
Immune and stress response/inflammation |
19 |
7 |
26 |
99 |
49 |
148 |
|
Cell proliferation/apoptosis |
9 |
3 |
12 |
37 |
18 |
55 |
|
Cell adhesion/cytoskeleton |
10 |
1 |
11 |
76 |
8 |
84 |
|
|
||||||
|
Differentially expressed genes of LC and HC groups (ANOVA FDR < 0.05 and t-test compared to Con group P < 0.01) were analyzed according to standard GO biological process annotation and grouped into functional categories. |
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|
Kleemann et al. Genome Biology 2007 8:R200 doi:10.1186/gb-2007-8-9-r200 |
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