Table 2

Overview of genes that are differentially expressed in response to cholesterol

LC

HC



GO category

Up

Down

Total

Up

Down

Total


Lipid and lipoprotein metabolism (includes cholesterol and steroid metabolism)

8

50

58

37

114

151

Protein metabolism (includes protein folding and breakdown)

34

14

48

143

98

241

Other metabolism (includes carbohydrate metabolism)

32

19

51

122

130

252

Generation of precursor metabolites and energy

10

15

25

24

47

71

Transport

31

15

46

125

77

202

Immune and stress response/inflammation

19

7

26

99

49

148

Cell proliferation/apoptosis

9

3

12

37

18

55

Cell adhesion/cytoskeleton

10

1

11

76

8

84


Differentially expressed genes of LC and HC groups (ANOVA FDR < 0.05 and t-test compared to Con group P < 0.01) were analyzed according to standard GO biological process annotation and grouped into functional categories.

Kleemann et al. Genome Biology 2007 8:R200   doi:10.1186/gb-2007-8-9-r200

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