Similarities and differences between our dataset and other bronchial airway datasets. (a) GSEA was used to determine if there was a gene expression relationship between other airway datasets (see Table 3 for a description of conditions 1 and 2) and our dataset based on the genes we identified to be regulated by smoking. The normalized enrichment score is plotted for datasets that had a FDR < 0.25. (b) Gene lists derived from functional categories and chromosomal locations found to be over-represented by EASE analysis in our dataset were tested for enrichment in our dataset and the other ten datasets using GSEA. A false-color heatmap of the positive (red) and negative (blue) normalized enrichment scores (with a FDR < 0.25) is shown for each category. An asterisk indicates the results passed a stricter FDR < 0.05. The nine datasets and conditions that yielded significant results in either (a) or (b) are indicated in Table 3 by the presence of a single asterisk.
Beane et al. Genome Biology 2007 8:R201 doi:10.1186/gb-2007-8-9-r201