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This article is part of the supplement: Transposons in vertebrate functional genomics

Review

Transposons for cancer gene discovery: Sleeping Beauty and beyond

Lara S Collier* and David A Largaespada

Author Affiliations

The Department of Genetics, Cell Biology and Development, The Cancer Center, The University of Minnesota Twin Cities, Church St SE, Minneapolis, Minnesota 55455, USA

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Genome Biology 2007, 8(Suppl 1):S15  doi:10.1186/gb-2007-8-s1-s15

Published: 31 October 2007

Abstract

The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.