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This article is part of the supplement: Transposons in vertebrate functional genomics

Review

The DNA transposon Minos as a tool for transgenesis and functional genomic analysis in vertebrates and invertebrates

Anastasios Pavlopoulos12, Stefan Oehler1, Maria G Kapetanaki13 and Charalambos Savakis14*

Author Affiliations

1 Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Vassilika Vouton, PO Box 1385, Heraklion 71110, Crete, Greece

2 Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK

3 Department of Molecular Genetics and Biochemistry, School of Medicine, and Cancer Institute, University of Pittsburgh, Hillman Cancer Center, Centre Avenue, Pittsburgh, Philadelphia 15213, USA

4 Medical School, University of Crete, Voutes, PO Box 2208, Heraklion 71003, Crete, Greece

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Genome Biology 2007, 8(Suppl 1):S2  doi:10.1186/gb-2007-8-s1-s2

Published: 31 October 2007

Abstract

Transposons are powerful tools for conducting genetic manipulation and functional studies in organisms that are of scientific, economic, or medical interest. Minos, a member of the Tc1/mariner family of DNA transposons, exhibits a low insertional bias and transposes with high frequency in vertebrates and invertebrates. Its use as a tool for transgenesis and genome analysis of rather different animal species is described.