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This article is part of the supplement: Transposons in vertebrate functional genomics

Review

Transposons as tools for enhancer trap screens in vertebrates

Vladimir Korzh

Author Affiliations

Institute of Molecular and Cell Biology, Biopolis Dr., Proteos, 138673, Singapore; Department of Biological Sciences, Science Drive 4, National University of Singapore, 117543 Singapore

Genome Biology 2007, 8(Suppl 1):S8  doi:10.1186/gb-2007-8-s1-s8

Published: 31 October 2007

Abstract

DNA transposons are efficient tools in transgenesis and have therefore become popular in the analysis of the regulatory genome in vertebrates via enhancer trap screens. Here, I discuss recent progress in this field of research, with a focus on the application of one of these transposons, namely the medaka fish derived Tol2, to enhancer trapping in zebrafish, and how this approach compares with others that have a similar objective.