|
Comparison of gene knockout strategies in rodents |
|||
| Criteria |
Retroviral |
ENU |
Retrotransposon |
|
|
|||
| Disrupt genes completely |
Yes |
No |
Yes |
| Random mutation |
No |
Yes |
Yes |
| High frequency mutation |
Yes |
Yes |
Yes |
| Quickly map mutations |
Yes |
No |
Yes |
| Efficiently create knockout animals |
No |
Yes |
Yes |
|
ENU, N-ethyl-N-nitrosourea. | |||
Ostertag et al. Genome Biology 2007 8(Suppl 1):S16 doi:10.1186/gb-2007-8-s1-s16 |
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