Figure 1.

Common and distinct functional outputs of three enzymes that deubiquitinate H2A. These three enzymes - MYSMI, USP16 and USP3 - have been proposed to remove ubiquitin from Ub-H2A. MYSMI and USP16 share a common role in transcriptional control of potentially distinct gene cohorts, whereas USP16 and USP3 DUB activities have been implicated in cell-cycle progression. USP3 may indirectly influence cycling of cells through effects on DNA damage repair pathways.