Figure 2.

Domains within Groucho/TLE/Grg family proteins. Gro/TLE/Grg proteins are characterized by five evolutionarily conserved and distinct domains. The amino-terminal Q domain contains two predicted amphipathic α-helices (AH1 and AH2) and mediates oligomerization and protein-protein interactions. The three central domains, GP, CcN and SP, are less well conserved across evolution and their structures are not known. The WD domain is highly conserved across evolution, folds to form a seven-bladed β-propeller and mediates protein-protein interactions.