Figure 2.

Screenshots of MetaReg core functions. (a) The model display. In the main window, the model canvas allows dynamic model layout, model simulation and display of observations (measurements) versus predictions under a particular experiment for each of the model variables. On the right (top to bottom): satellite view of the current model, variable lookup and variable property viewer. (b) Selection of variables from a gene database (NCBI Gene or SGD). (c) Formulation of a variable's logic using the wizard. (d) The discrepancy matrix, which compares predicted and observed levels for all experiments (columns) and variables (rows). (e) A logic suggested by MetaReg's model refinement algorithm. The suggestion can be further edited by the user, and incorporated into the model.