Genome Biology
Volume 9
Issue 1 |
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  MethodCPSARST: an efficient circular permutation search tool applied to the detection of novel protein structural relationshipsWei-Cheng Lo  and Ping-Chiang Lyu  Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 30013, Taiwan  author email corresponding author email
Genome Biology 2008,
9:R11doi:10.1186/gb-2008-9-1-r11
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| Published: |
18 January 2008 |
Subject areas: Biochemistry and structural biology, Bioinformatics Abstract
Circular permutation of a protein can be visualized as if the original amino- and carboxyl termini were linked and new ones created elsewhere. It has been well-documented that circular permutants usually retain native structures and biological functions. Here we report CPSARST (Circular Permutation Search Aided by Ramachandran Sequential Transformation) to be an efficient database search tool. In this post-genomics era, when the amount of protein structural data is increasing exponentially, it provides a new way to rapidly detect novel relationships among proteins. | 
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