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Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

Corneliu Henegar12*, Joan Tordjman12, Vincent Achard12, Danièle Lacasa12, Isabelle Cremer123, Michèle Guerre-Millo12, Christine Poitou124, Arnaud Basdevant124, Vladimir Stich5, Nathalie Viguerie5678, Dominique Langin5678, Pierre Bedossa109, Jean-Daniel Zucker111 and Karine Clement124

Author Affiliations

1 INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique and Eq. 13, Paris, F-75006 France

2 Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris, F-75006 France

3 Paris Descartes University, UMR-S 872, Paris, F-75006 France

4 Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Nutrition and Endocrinology department, Paris, F-75013 France

5 Franco-Czech Laboratory for Clinical Research on Obesity, INSERM and 3rd Faculty of Medicine, Charles University, Prague, CZ-10000, Czech Republic

6 INSERM, U858, Obesity Research Laboratory, I2MR, Toulouse, F-31432 France

7 Paul Sabatier University, Louis Bugnard Institute IFR31, Toulouse, F-31432 France

8 Centre Hospitalier Universitaire de Toulouse, Toulouse, F-31059 France

9 Assistance Publique-Hôpitaux de Paris (AP-HP), Beaujon Hospital, Pathology department, Clichy, F-92110 France

10 CNRS, UMR 8149, Clichy, F-92110 France

11 IRD UR Géodes, Centre IRD de l'Ile de France, Bondy, F-93143 France

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Genome Biology 2008, 9:R14  doi:10.1186/gb-2008-9-1-r14

Published: 21 January 2008

Additional files

Additional data file 1:

Results of the differential expression analysis performed in human pre-adipocytes cultured with AcMC medium.

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Additional data file 2:

ECM-related genes showing significant differential expression in obese WAT compared to lean controls, and in pre-adipocytes cultured with AcMC medium.

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