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Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

Corneliu Henegar1,2 email, Joan Tordjman1,2 email, Vincent Achard1,2 email, Danièle Lacasa1,2 email, Isabelle Cremer1,2,3 email, Michèle Guerre-Millo1,2 email, Christine Poitou1,2,4 email, Arnaud Basdevant1,2,4 email, Vladimir Stich5 email, Nathalie Viguerie5,6,7,8 email, Dominique Langin5,6,7,8 email, Pierre Bedossa9,10 email, Jean-Daniel Zucker1,11 email and Karine Clement1,2,4 email

INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique and Eq. 13, Paris, F-75006 France

Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris, F-75006 France

Paris Descartes University, UMR-S 872, Paris, F-75006 France

Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Nutrition and Endocrinology department, Paris, F-75013 France

Franco-Czech Laboratory for Clinical Research on Obesity, INSERM and 3rd Faculty of Medicine, Charles University, Prague, CZ-10000, Czech Republic

INSERM, U858, Obesity Research Laboratory, I2MR, Toulouse, F-31432 France

Paul Sabatier University, Louis Bugnard Institute IFR31, Toulouse, F-31432 France

Centre Hospitalier Universitaire de Toulouse, Toulouse, F-31059 France

Assistance Publique-Hôpitaux de Paris (AP-HP), Beaujon Hospital, Pathology department, Clichy, F-92110 France

10  CNRS, UMR 8149, Clichy, F-92110 France

11  IRD UR Géodes, Centre IRD de l'Ile de France, Bondy, F-93143 France

author email corresponding author email

Genome Biology 2008, 9:R14doi:10.1186/gb-2008-9-1-r14

Published: 21 January 2008

Subject areas: Bioinformatics, Cell biology, Physiology


Additional files

Additional data file 1:

Results of the differential expression analysis performed in human pre-adipocytes cultured with AcMC medium.

Format: XLS Size: 6.8MB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 2:

ECM-related genes showing significant differential expression in obese WAT compared to lean controls, and in pre-adipocytes cultured with AcMC medium.

Format: PDF Size: 138KB Download file

This file can be viewed with: Adobe Acrobat Reader


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