Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

doi:10.1186/gb-2008-9-1-r14

Genome Biology

Volume 9
Issue 1

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Henegar C
Tordjman J
Achard V
Lacasa D
Cremer I
Guerre-Millo M
Poitou C
Basdevant A
Stich V
Viguerie N
Langin D
Bedossa P
Zucker JD
Clement K

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Henegar C
Tordjman J
Achard V
Lacasa D
Cremer I
Guerre-Millo M
Poitou C
Basdevant A
Stich V
Viguerie N
Langin D
Bedossa P
Zucker JD
Clement K
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Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

Corneliu Henegar¹^,2 , Joan Tordjman¹^,2 , Vincent Achard¹^,2 , Danièle Lacasa¹^,2 , Isabelle Cremer¹^,2^,3 , Michèle Guerre-Millo¹^,2 , Christine Poitou¹^,2^,4 , Arnaud Basdevant¹^,2^,4 , Vladimir Stich⁵ , Nathalie Viguerie⁵^,6^,7^,8 , Dominique Langin⁵^,6^,7^,8 , Pierre Bedossa⁹^,10 , Jean-Daniel Zucker¹^,11 and Karine Clement¹^,2^,4

¹INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique and Eq. 13, Paris, F-75006 France

²Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris, F-75006 France

³Paris Descartes University, UMR-S 872, Paris, F-75006 France

⁴Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Nutrition and Endocrinology department, Paris, F-75013 France

⁵Franco-Czech Laboratory for Clinical Research on Obesity, INSERM and 3rd Faculty of Medicine, Charles University, Prague, CZ-10000, Czech Republic

⁶INSERM, U858, Obesity Research Laboratory, I2MR, Toulouse, F-31432 France

⁷Paul Sabatier University, Louis Bugnard Institute IFR31, Toulouse, F-31432 France

⁸Centre Hospitalier Universitaire de Toulouse, Toulouse, F-31059 France

⁹Assistance Publique-Hôpitaux de Paris (AP-HP), Beaujon Hospital, Pathology department, Clichy, F-92110 France

¹⁰CNRS, UMR 8149, Clichy, F-92110 France

¹¹IRD UR Géodes, Centre IRD de l'Ile de France, Bondy, F-93143 France

author email corresponding author email

Genome Biology 2008, 9:R14doi:10.1186/gb-2008-9-1-r14


Published:	21 January 2008

Subject areas: Bioinformatics, Cell biology, Physiology

Additional files

Additional data file 1:

Results of the differential expression analysis performed in human pre-adipocytes cultured with AcMC medium.

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Additional data file 2:

ECM-related genes showing significant differential expression in obese WAT compared to lean controls, and in pre-adipocytes cultured with AcMC medium.

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