Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

Corneliu Henegar^1,2 , Joan Tordjman^1,2 , Vincent Achard^1,2 , Danièle Lacasa^1,2 , Isabelle Cremer^1,2,3 , Michèle Guerre-Millo^1,2 , Christine Poitou^1,2,4 , Arnaud Basdevant^1,2,4 , Vladimir Stich⁵ , Nathalie Viguerie^5,6,7,8 , Dominique Langin^5,6,7,8 , Pierre Bedossa^9,10 , Jean-Daniel Zucker^1,11 and Karine Clement^1,2,4

¹INSERM, UMR-S 872, Les Cordeliers, Eq. 7 Nutriomique and Eq. 13, Paris, F-75006 France

²Pierre et Marie Curie-Paris 6 University, Cordeliers Research Center, UMR-S 872, Paris, F-75006 France

³Paris Descartes University, UMR-S 872, Paris, F-75006 France

⁴Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié Salpêtrière Hospital, Nutrition and Endocrinology department, Paris, F-75013 France

⁵Franco-Czech Laboratory for Clinical Research on Obesity, INSERM and 3rd Faculty of Medicine, Charles University, Prague, CZ-10000, Czech Republic

⁶INSERM, U858, Obesity Research Laboratory, I2MR, Toulouse, F-31432 France

⁷Paul Sabatier University, Louis Bugnard Institute IFR31, Toulouse, F-31432 France

⁸Centre Hospitalier Universitaire de Toulouse, Toulouse, F-31059 France

⁹Assistance Publique-Hôpitaux de Paris (AP-HP), Beaujon Hospital, Pathology department, Clichy, F-92110 France

¹⁰CNRS, UMR 8149, Clichy, F-92110 France

¹¹IRD UR Géodes, Centre IRD de l'Ile de France, Bondy, F-93143 France