Table 2

Significant correlations between BMI and expression profiles of genes annotated with themes composing the GO Biological Process interaction modules in obese WAT

EntrezGene gene ID

Gene symbol

Gene name

Fold*

Rs

FDR

Tissular fraction§


Module 1

1880

EBI2

Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)

1.63

0.62

0.00

SVF

5788

PTPRC

protein tyrosine phosphatase,receptor type,C

1.74

0.61

0.00

SVF

1520

CTSS

cathepsin S

1.53

0.54

0.00

SVF

51107

APH1A

anterior pharynx defective 1 homolog A

1.40

0.50

0.01

SVF

1439

CSF2RB

colony stimulating factor 2 receptor,beta,low-affinity (granulocyte-macrophage)

2.03

0.49

0.01

SVF

3937

LCP2

lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76 kDa)

1.87

0.49

0.01

SVF

919

CD247

CD247 molecule

1.36

0.49

0.01

SVF

3301

DNAJA1

DnaJ (Hsp40)homolog,subfamily A,member 1

1.46

0.48

0.02

SVF

131566

DCBLD2

discoidin,CUB and LCCL domain containing 2

2.00

0.47

0.02

-

9448

MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

1.40

0.47

0.02

-

3091

HIF1A

hypoxia-inducible factor 1,alpha subunit (basic helix-loop-helix transcription factor)

1.32

0.46

0.02

SVF

11183

MAP4K5

mitogen-activated protein kinase kinase kinase kinase 5

1.35

0.44

0.03

A

23678

SGK3

serum/glucocorticoid regulated kinase family,member 3

1.48

0.44

0.03

-

667

DST

dystonin

1.66

0.44

0.03

SVF

10954

PDIA5

protein disulfide isomerase family A,member 5

1.34

0.43

0.03

-

2113

ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1

1.65

0.41

0.03

-

8506

CNTNAP1

contactin associated protein 1

1.24

0.41

0.03

SVF

10437

IFI30

interferon,gamma-inducible protein 30

2.35

0.40

0.04

SVF

10095

ARPC1B

actin related protein 2/3 complex,subunit 1B,41 kDa

1.74

0.39

0.04

SVF

Module 2

5256

PHKA2

phosphorylase kinase,alpha 2

0.67

-0.67

0.00

A

3643

INSR

insulin receptor

0.67

-0.66

0.00

-

23604

DAPK2

death-associated protein kinase 2

0.44

-0.61

0.00

A

1384

CRAT

carnitine acetyltransferase

0.62

-0.61

0.00

A

1968

EIF2S3

eukaryotic translation initiation factor 2,subunit 3 gamma,52 kDa

0.63

-0.58

0.00

-

11000

SLC27A3

solute carrier family 27 (fatty acid transporter),member 3

0.76

-0.56

0.01

SVF

10572

SIVA1

CD27-binding (Siva)protein

0.69

-0.54

0.01

A

6158

RPL28

ribosomal protein L28

0.66

-0.53

0.01

SVF

6206

RPS12

ribosomal protein S12

0.53

-0.52

0.01

SVF

11224

RPL35

ribosomal protein L35

0.65

-0.51

0.01

SVF

6187

RPS2

ribosomal protein S2

0.77

-0.51

0.01

-

51069

MRPL2

mitochondrial ribosomal protein L2

0.59

-0.50

0.01

A

93974

ATPIF1

ATPase inhibitory factor 1

0.79

-0.49

0.01

-

134

ADORA1

adenosine A1 receptor

0.75

-0.48

0.01

A

51023

MRPS18C

mitochondrial ribosomal protein S18C

0.74

-0.48

0.01

A

35

ACADS

acyl-CoA dehydrogenase,C-2 to C-3 short chain

0.69

-0.48

0.01

A

6227

RPS21

ribosomal protein S21

0.62

-0.48

0.02

SVF

4694

NDUFA1

NADH dehydrogenase (ubiquinone)1 alpha subcomplex,1,7.5 kDa

0.86

-0.48

0.02

A

1936

EEF1D

eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

0.75

-0.47

0.02

SVF

3991

LIPE

lipase,hormone-sensitive

0.76

-0.46

0.02

A

10063

COX17

COX17 cytochrome c oxidase assembly homolog

0.71

-0.45

0.02

-

5346

PLIN

perilipin

0.71

-0.45

0.02

A

27335

EIF3S12

eukaryotic translation initiation factor 3,subunit 12

0.73

-0.43

0.03

A

84545

MRPL43

mitochondrial ribosomal protein L43

0.78

-0.43

0.03

A

8613

PPAP2B

phosphatidic acid phosphatase type 2B

0.50

-0.42

0.03

SVF

1983

EIF5

eukaryotic translation initiation factor 5

0.76

-0.42

0.03

SVF

1611

DAP

death-associated protein

0.70

-0.40

0.04

SVF

6166

RPL36AL

ribosomal protein L36a-like

0.73

-0.40

0.04

-

6152

RPL24

ribosomal protein L24

0.74

-0.40

0.04

SVF

122970

ACOT4

acyl-CoA thioesterase 4

0.65

-0.40

0.04

A

5255

PHKA1

phosphorylase kinase,alpha 1

0.81

-0.39

0.04

-

6165

RPL35A

ribosomal protein L35a

0.72

-0.39

0.04

SVF


*Gene expression fold change in the obese versus lean condition. Spearman's correlation coefficients between gene expression profiles and the BMI of analyzed subjects. The q-values obtained by applying the Storey (2002) FDR method to adjust the p values computed with the Spearman's correlation test. §Genes expressed predominantly in one of the two main cellular fractions of the adipose tissue: mature adipocytes (A) or the stroma vascular fraction (SVF). Hyphens indicate genes for which no significantly predominant expression in one of the two main cellular fractions of the adipose tissue could be detected.

Henegar et al. Genome Biology 2008 9:R14   doi:10.1186/gb-2008-9-1-r14

Open Data