Research
Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus
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* Corresponding author: Christoph Welsch christophwelsch@gmx.net
- † Equal contributors
1 Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123 Saarbrücken, Germany
2 Department of Internal Medicine I, Johann Wolfgang Goethe University Hospital, 60590 Frankfurt/Main, Germany
3 Department of Internal Medicine II, Saarland University Hospital, 66421 Homburg/Saar, Germany
Genome Biology 2008, 9:R16 doi:10.1186/gb-2008-9-1-r16
Published: 23 January 2008Additional files
Additional data file 1:
Figure S1 illustrates NS3-4A protease-ligand interactions. Figure S2 shows the complete network of non-covalent, H-bond and van der Waals, interactions of the NS3-4A protease for the PDB entry 1RTL. Figure S3 gives results of SCH 503034 and VX-950 inhibitor studies using an HCV V36G mutant replicon assay. Table S1 lists HCV genotypes included into the multiple sequence alignment of Figure 9.
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