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Enzymatic in vitro drug resistance data for telaprevir (VX-950) |
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| IC50 mean (nM) |
IC50 range (nM) |
IC50 (fold changes) |
|
|
|
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| HCV genotype 1a |
70 |
- |
- |
| V36A/G/L/M |
226 |
110-444 |
1.7-6.9 |
| T54S |
120 |
- |
1.9 |
| T54A |
749 |
- |
11.7 |
| R155G/I/K/L/M/S/T |
538 |
275-1,050 |
4.3-16.4 |
| A156I/T/V |
29,800 |
12,500-50,000 |
195-781 |
| A156S |
1,400 |
- |
21.9 |
|
Enzymatic in vitro resistance data for VX-950 (mean IC50 values, IC50 range and IC50 fold changes) are compared to the reference strain HCV-H, genotype 1a (UniProtKB accession number P27958) and are shown for VX-950 inhibition of wild-type and mutant NS3-4A proteases (V36, T54, R155 and A156) [19,26,28]. | |||
Welsch et al. Genome Biology 2008 9:R16 doi:10.1186/gb-2008-9-1-r16 |
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