Genome Biology

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Open Access Research

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

Scott H Robbins1,10,2,3, Thierry Walzer1,2,3, Doulaye Dembélé4,5,6,7, Christelle Thibault4,5,6,7, Axel Defays1,2,3, Gilles Bessou1,2,3, Huichun Xu8, Eric Vivier1,2,3,9, MacLean Sellars4,5,6,7, Philippe Pierre1,2,3, Franck R Sharp8, Susan Chan4,5,6,7, Philippe Kastner4,5,6,7 and Marc Dalod1,2,3*

Author Affiliations

1 CIML (Centre d'Immunologie de Marseille-Luminy), Université de la Méditerranée, Parc scientifique de Luminy case 906, Marseille F-13288, France

2 U631, INSERM (Institut National de la Santé et de la Recherche Médicale), Parc scientifique de Luminy case 906, Marseille F-13288, France

3 UMR6102, CNRS (Centre National de la Recherche Scientifique), Parc scientifique de Luminy case 906, Marseille F-13288, France

4 Hematopoiesis and leukemogenesis in the mouse, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), rue Laurent Fries, ILLKIRCH F-67400, France

5 U596, INSERM, rue Laurent Fries, ILLKIRCH F-67400, France

6 UMR7104, CNRS, rue Laurent Fries, ILLKIRCH F-67400, France

7 UM41, Université Louis Pasteur, rue Laurent Fries, Strasbourg F-67400, France

8 The Medical Investigation of Neurodevelopmental Disorders Institute, University of California at Davis Medical Center, Sacramento, CA 95817, USA

9 Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Boulevard Baille, Marseille F-13385, France

10 Current address: Genomics Institute of the Novartis Research Foundation, John Jay Hopkins Drive, San Diego, CA 92121, USA

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Genome Biology 2008, 9:R17 doi:10.1186/gb-2008-9-1-r17

Published: 24 January 2008

Additional files

Additional file 1:

Raw data for the mouse gene chip compendium.

Format: XLS Size: 2.5MB Download file

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Additional file 2:

Raw data for the human gene chip compendium.

Format: XLS Size: 5.9MB Download file

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Additional file 3:

Raw data for the human/mouse gene chip compendium.

Format: XLS Size: 2.8MB Download file

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Additional file 4:

Raw data for the IKDC gene chip compendium.

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Additional file 5:

Mouse DC subset gene signatures according to our datasets with confirmation from two other independent datasets (one for pDCs and one for cDC subsets).

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Additional file 6:

Results of PCA for investigation of the relationships between in vitro derived GM-CSF DCs and LN-DCs in mouse and human.

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Additional file 7:

Real-time PCR data for the pattern of expression of 27 genes across mouse leukocyte subsets.

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Additional file 8:

PACSIN1 expression in human pDCs versus PBMCs by RT-PCR and western blotting.

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