Table 11 |
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|
Comparison of the transcriptome of mouse GM-CSF BM-derived DCs to that of spleen DCs |
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|
Ratio to monocytes |
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|
|
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|
Probe set ID |
Name |
Mono |
Mono(2) |
MΦ |
BM-MΦ |
BM-DC |
pDC |
CD8 DC |
CD11b DC |
|
|
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|
Myeloid signature genes |
|||||||||
|
1420804_s_at |
Clec4d |
4,934 |
0.65 |
0.49 |
0.75 |
0.41 |
- |
- |
- |
|
1420330_at |
Clec4e |
5,511 |
0.11 |
0.22 |
0.23 |
0.11 |
- |
- |
- |
|
1450808_at |
Fpr1 |
119 |
1.91 |
- |
5.55 |
2.41 |
- |
- |
- |
|
1452001_at |
Nfe2 |
139 |
1.44 |
- |
- |
3.31 |
- |
- |
- |
|
1450919_at |
Mpp1 |
1,888 |
0.15 |
2.05 |
1.75 |
0.52 |
0.23 |
0.09 |
0.07 |
|
1419609_at |
Ccr1 |
403 |
1.27 |
4.04 |
0.53 |
3.98 |
0.2 |
- |
- |
|
1417061_at |
Slc40a1 |
2,588 |
0.68 |
- |
0.56 |
0.07 |
0.01 |
0.01 |
0.02 |
|
1448756_at |
S100a9 |
8,664 |
1.2 |
- |
0.01 |
0.99 |
0 |
0 |
- |
|
1417268_at |
Cd14 |
6,745 |
0.1 |
0.3 |
0.6 |
0.19 |
0.02 |
0.01 |
0.01 |
|
1418163_at |
Tlr4 |
464 |
0.1 |
0.36 |
0.93 |
0.66 |
- |
0.07 |
0.06 |
|
1448620_at |
Fcgr3 |
1,471 |
2.02 |
3.56 |
2.15 |
2.46 |
- |
0.02 |
0.07 |
|
1422953_at |
Fpr-rs2 |
839 |
2.04 |
0.12 |
0.85 |
1.58 |
- |
- |
0.05 |
|
1419132_at |
Tlr2 |
1,763 |
0.11 |
0.42 |
0.24 |
0.48 |
0.04 |
0.1 |
0.14 |
|
1417566_at |
Abhd5 |
170 |
0.19 |
0.72 |
0.86 |
2.2 |
0.18 |
0.45 |
0.25 |
|
1415814_at |
Atp6v1b2 |
1,556 |
0.22 |
2.75 |
1.57 |
1.43 |
0.18 |
0.27 |
0.24 |
|
1427327_at |
Pilra |
434 |
1.53 |
0.16 |
0.47 |
2.29 |
0.1 |
- |
0.21 |
|
1418888_a_at |
Sepx1 |
4,416 |
0.48 |
0.34 |
0.31 |
0.56 |
0.03 |
0.04 |
0.05 |
|
1438928_x_at |
Ninj1 |
5,574 |
0.03 |
1.3 |
0.46 |
0.36 |
0.03 |
0.02 |
0.02 |
|
1448881_at |
Hp |
400 |
3.19 |
0.14 |
0.06 |
3.09 |
- |
- |
- |
|
1449453_at |
Bst1 |
340 |
1.08 |
4.97 |
0.58 |
1.61 |
0.21 |
0.51 |
- |
|
1419394_s_at |
S100a8 |
10,190 |
1.37 |
0.01 |
0.01 |
0.66 |
- |
0 |
- |
|
1437200_at |
Fcho2 |
311 |
1.09 |
1.32 |
1.06 |
0.76 |
0.28 |
0.2 |
0.33 |
|
1418806_at |
Csf3r |
2,598 |
0.2 |
0.14 |
0.19 |
0.11 |
- |
- |
0.03 |
|
1439902_at |
C5ar1 |
317 |
8.21 |
0.19 |
1.63 |
0.37 |
- |
- |
- |
|
1456046_at |
Cd93 |
1,559 |
0.1 |
0.49 |
1.18 |
0.33 |
0.02 |
- |
- |
|
1418901_at |
Cebpb |
3,797 |
0.14 |
0.7 |
0.22 |
0.42 |
0.02 |
0.01 |
0.02 |
|
1420699_at |
Clec7a |
2,748 |
0.83 |
2.62 |
0.44 |
1.71 |
0.08 |
0.06 |
0.54 |
|
Pan-DC signature genes |
|||||||||
|
1419538_at |
Flt3 |
51 |
0.74 |
- |
- |
0.7 |
16.2 |
25.32 |
17.78 |
|
1427619_a_at |
Sh3tc1 |
- |
>1.1 |
>6.8 |
>2.8 |
>4.9 |
>5.2 |
>6.5 |
>4.6 |
|
1424489_a_at |
Trit1 |
54 |
7.28 |
0.44 |
0.76 |
1.23 |
9.03 |
11.53 |
8.63 |
|
1428744_s_at |
Bri3bp |
161 |
0.84 |
0.6 |
1.44 |
3.28 |
6.09 |
7.24 |
5.98 |
|
1448923_at |
Prkra |
72 |
1.28 |
0.77 |
2.89 |
2.57 |
4.45 |
7.88 |
3.63 |
|
1434880_at |
Etv6 |
140 |
5.39 |
1.52 |
0.74 |
1.75 |
5.79 |
6.02 |
7.78 |
|
1416108_a_at |
Tmed3 |
154 |
0.81 |
3.74 |
2.63 |
4.65 |
10.17 |
4.48 |
3 |
|
1436633_at |
Bahcc1 |
41 |
1.77 |
- |
0.83 |
- |
1.8 |
3.88 |
2.35 |
|
1437378_x_at |
Scarb1 |
97 |
5.02 |
1.25 |
2.61 |
3.17 |
7.41 |
8.27 |
4.05 |
|
cDC signature genes |
|||||||||
|
1435108_at |
Arhgap22 |
63 |
- |
- |
2.37 |
0.57 |
0.59 |
10.65 |
4.43 |
|
1429168_at |
Btbd4 |
129 |
0.19 |
0.27 |
- |
0.47 |
0.81 |
3.89 |
3.8 |
|
1425294_at |
Slamf8 |
146 |
1.06 |
39.89 |
1.83 |
1.77 |
0.39 |
8.48 |
5.27 |
|
1453076_at |
9130211I03Rik |
36 |
1.61 |
2.85 |
1.03 |
13.11 |
0.62 |
30.94 |
25.64 |
|
1436907_at |
Nav1 |
102 |
1.59 |
0.74 |
2.63 |
1.96 |
1.21 |
6.08 |
13.14 |
|
1421210_at |
C2ta |
125 |
0.17 |
1.79 |
0.19 |
0.93 |
1.46 |
5.94 |
5.43 |
|
1423122_at |
Avpi1 |
150 |
0.32 |
- |
0.2 |
0.86 |
0.61 |
2.47 |
7.62 |
|
1416627_at |
Spint1 |
- |
>1.5 |
>1.1 |
- |
>22.9 |
>1.6 |
>25.7 |
>30.6 |
|
1450667_a_at |
Cs |
396 |
2.47 |
0.9 |
1.19 |
3.54 |
2.83 |
4.64 |
4.5 |
|
APC signature genes |
|||||||||
|
1419744_at |
H2-DMb2 |
451 |
0.12 |
0.1 |
0.08 |
1.47 |
0.45 |
0.48 |
1.69 |
|
1443687_x_at |
H2-DMb1 |
547 |
0.56 |
0.13 |
0.11 |
1.56 |
1.06 |
0.82 |
3.13 |
|
1434955_at |
March1 |
80 |
32.64 |
0.83 |
1.51 |
3.48 |
3.73 |
13.4 |
8.57 |
|
1448143_at |
Aldh2 |
867 |
0.47 |
2.14 |
2.07 |
1.32 |
0.95 |
0.65 |
0.45 |
|
1419406_a_at |
Bcl11a |
60 |
1.47 |
0.34 |
- |
0.71 |
20.41 |
7.63 |
9.19 |
|
1422755_at |
Btk |
416 |
0.56 |
0.76 |
1.3 |
1.15 |
0.88 |
1.45 |
1.17 |
|
1418365_at |
Ctsh |
1,393 |
0.81 |
3.9 |
2.19 |
2.15 |
3.69 |
1.24 |
2.16 |
|
1417025_at |
H2-Eb1 |
6,385 |
0.13 |
0.39 |
0.04 |
0.8 |
0.9 |
1.31 |
1.33 |
|
1425519_a_at |
Cd74 |
8,377 |
0.36 |
0.95 |
0.2 |
0.9 |
0.83 |
0.97 |
0.98 |
|
1417868_a_at |
Ctsz |
7,061 |
0.05 |
1.16 |
0.95 |
0.85 |
0.5 |
0.3 |
0.49 |
|
1423393_at |
Clic4 |
2,807 |
0.07 |
2.04 |
0.84 |
0.57 |
0.69 |
0.72 |
0.67 |
|
1430570_at |
Kynu |
31 |
1.23 |
- |
- |
3.21 |
12.87 |
5.16 |
11.56 |
|
1435745_at |
5031439G07Rik |
356 |
0.95 |
0.73 |
2.76 |
2.51 |
3.23 |
3.14 |
4.28 |
|
1458299_s_at |
Nfkbie |
767 |
0.4 |
0.62 |
0.1 |
0.44 |
1.25 |
0.65 |
1.27 |
|
1423768_at |
Unc93b1 |
663 |
0.1 |
2.27 |
2.69 |
1.46 |
1.2 |
0.93 |
0.91 |
|
Non-DC signature genes |
|||||||||
|
1424375_s_at |
Gimap4 |
362 |
0.14 |
0.29 |
- |
0.1 |
0.11 |
- |
0.11 |
|
1424380_at |
Vps37b |
313 |
0.44 |
0.46 |
0.45 |
0.26 |
0.28 |
0.28 |
0.27 |
|
1425396_a_at |
Lck |
118 |
- |
0.57 |
0.2 |
0.32 |
0.21 |
- |
0.17 |
|
1433694_at |
Pde3b |
352 |
0.69 |
0.15 |
0.16 |
0.42 |
- |
0.65 |
0.35 |
|
|
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|
*Average expression across replicates. Genes for which expression between mouse bone-marrow derived GM-CSF DCs (BM-DCs) and spleen DCs or spleen cDCs varies more than two-fold are shown in bold. BM-MΦ, mouse bone marrow-derived M-CSF macrophages; MΦ, peritoneal mouse macrophages; mono, mouse spleen monocytes from the SB laboratory; mono(2), mouse spleen monocytes from the BP laboratory, as listed in Table 1. |
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|
Robbins et al. Genome Biology 2008 9:R17 doi:10.1186/gb-2008-9-1-r17 |
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