Table 9 |
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|
Expression of APC, DC and myeloid signature genes in CD16 cells |
||||||||||
|
Dendritic cells |
Myeloid cells |
Ratio to DC |
||||||||
|
|
|
|
||||||||
|
Probe set ID |
Gene |
BDCA1 |
BDCA3 |
pDC |
Mono |
Neu |
CD16 cells |
CD16 |
Mono |
Neu |
|
|
||||||||||
|
APC signature genes |
||||||||||
|
203932_at |
HLA-DMB |
8,636* |
7,929 |
5,894 |
5,194 |
173 |
2,581 |
0.3 |
0.6 |
<0.1 |
|
205101_at |
CIITA |
2,803 |
2,354 |
724 |
531 |
50 |
226 |
<0.1 |
0.2 |
<0.1 |
|
219574_at |
MARCH1 |
587 |
777 |
544 |
1,214 |
58 |
810 |
1 |
2 |
<0.1 |
|
201425_at |
ALDH2 |
9,279 |
7,841 |
6,034 |
8,504 |
706 |
1,760 |
0.2 |
0.9 |
<0.1 |
|
222891_s_at |
BCL11A |
569 |
747 |
4,502 |
310 |
50 |
213 |
<0.1 |
<0.1 |
<0.1 |
|
205504_at |
BTK |
1,120 |
822 |
1,132 |
1,409 |
281 |
1,786 |
2 |
1 |
0.3 |
|
202295_s_at |
CTSH |
6,197 |
2,528 |
1,211 |
3,949 |
75 |
2,440 |
0.39 |
0.6 |
<0.1 |
|
213831_at |
DQA1 |
11,535 |
7,503 |
5,919 |
4,701 |
50 |
252 |
<0.1 |
0.4 |
<0.1 |
|
215536_at |
DQB2 |
432 |
391 |
157 |
180 |
81 |
52 |
0.1 |
0.4 |
0.2 |
|
209312_x_at |
DRB1 |
14,608 |
14,477 |
13,250 |
11,915 |
228 |
14,007 |
1 |
0.8 |
<0.1 |
|
209619_at |
CD74 |
12,533 |
12,210 |
10,498 |
9,020 |
867 |
7,383 |
0.6 |
0.7 |
<0.1 |
|
210042_s_at |
CTSZ |
906 |
848 |
692 |
370 |
153 |
673 |
0.7 |
0.4 |
0.2 |
|
201560_at |
CLIC4 |
920 |
305 |
663 |
3,023 |
165 |
354 |
0.4 |
3 |
0.2 |
|
217388_s_at |
KYNU |
2,414 |
1,059 |
2,204 |
3,516 |
50 |
3,738 |
2 |
1 |
<0.1 |
|
203927_at |
NFKBIE |
529 |
272 |
232 |
197 |
63 |
290 |
0.5 |
0.4 |
0.1 |
|
220998_s_at |
UNC93B1 |
966 |
850 |
1,938 |
862 |
449 |
1,235 |
0.6 |
0.4 |
0.2 |
|
Pan-DC signature genes |
||||||||||
|
206674_at |
FLT3 |
3,032 |
5,883 |
2,169 |
208 |
<50 |
<50 |
<0.1 |
<0.1 |
<0.1 |
|
219256_s_at |
SH3TC1 |
1,263 |
899 |
1,128 |
392 |
166 |
858 |
0.7 |
0.3 |
0.1 |
|
218617_at |
TRIT1 |
1,159 |
1,246 |
1,851 |
509 |
<50 |
339 |
0.2 |
0.3 |
<0.1 |
|
231810_at |
BRI3BP |
691 |
735 |
836 |
298 |
146 |
279 |
0.3 |
0.4 |
0.2 |
|
209139_s_at |
PRKRA |
846 |
1,067 |
1,440 |
316 |
74 |
497 |
0.3 |
0.2 |
<0.1 |
|
225764_at |
ETV6 |
2,172 |
2,432 |
1,726 |
1,143 |
938 |
941 |
0.4 |
0.5 |
0.4 |
|
208837_at |
TMED3 |
1,317 |
1,852 |
1,859 |
665 |
<50 |
1,022 |
0.6 |
0.4 |
<0.1 |
|
219218_at |
BAHCC1 |
87 |
86 |
250 |
<50 |
<50 |
<50 |
0.2 |
0.2 |
0.2 |
|
1552256_a_at |
SCARB1 |
325 |
425 |
942 |
165 |
128 |
59 |
<0.1 |
0.2 |
0.1 |
|
Non-DC signature genes |
||||||||||
|
219243_at |
GIMAP4 |
68 |
<50 |
<50 |
4,404 |
3,504 |
1,334 |
20 |
65 |
52 |
|
221704_s_at |
VPS37B |
54 |
<50 |
<50 |
593 |
962 |
487 |
9 |
11 |
18 |
|
204891_s_at |
LCK |
<50 |
<50 |
<50 |
92 |
181 |
65 |
- |
- |
- |
|
214582_at |
PDE3B |
78 |
<50 |
<50 |
129 |
625 |
114 |
1 |
2 |
8 |
|
Myeloid signature genes |
||||||||||
|
225987_at |
STEAP4 |
<50 |
<50 |
<50 |
877 |
6,090 |
<50 |
- |
- |
- |
|
1552773_at |
CLEC4D |
<50 |
<50 |
<50 |
452 |
520 |
<50 |
- |
- |
- |
|
222934_s_at |
CLEC4E |
214 |
124 |
133 |
2,837 |
5,885 |
229 |
1 |
13 |
28 |
|
202974_at |
MPP1 |
591 |
281 |
377 |
3,721 |
2,408 |
1,341 |
2 |
6 |
4 |
|
205098_at |
CCR1 |
93 |
<50 |
115 |
3,712 |
3,627 |
106 |
1 |
32 |
31 |
|
223044_at |
SLC40A1 |
769 |
276 |
321 |
5,018 |
3,444 |
<50 |
- |
6 |
4 |
|
224341_x_at |
TLR4 |
94 |
<50 |
<50 |
1,411 |
2,869 |
540 |
6 |
15 |
31 |
|
204714_s_at |
F5 |
<50 |
<50 |
<50 |
1,392 |
2,313 |
<50 |
- |
- |
- |
|
203561_at |
FCGR2A |
1,010 |
44 |
51 |
2,985 |
7,151 |
2,857 |
3 |
3 |
7 |
|
210772_at |
FPRL1 |
<50 |
<50 |
<50 |
389 |
3,454 |
70 |
3 |
- |
- |
|
204924_at |
TLR2 |
904 |
211 |
57 |
2,870 |
5,548 |
1,606 |
2 |
3 |
6 |
|
215223_s_at |
SOD2 |
1,474 |
946 |
528 |
3,528 |
7,599 |
4,236 |
3 |
2 |
5 |
|
222218_s_at |
PILRA |
1,168 |
150 |
136 |
2,899 |
4,035 |
3,982 |
3 |
2 |
3 |
|
210423_s_at |
SLC11A1 |
81 |
60 |
38 |
1,767 |
2,930 |
3,334 |
41 |
22 |
36 |
|
203045_at |
NINJ1 |
357 |
66 |
71 |
1,104 |
3,129 |
1,934 |
5 |
3 |
9 |
|
201669_s_at |
MARCKS |
521 |
389 |
<50 |
2,449 |
3,224 |
1,730 |
3 |
5 |
6 |
|
207697_x_at |
LILRB2 |
1,271 |
78 |
774 |
3,353 |
3,711 |
4,903 |
4 |
3 |
3 |
|
1553297_a_at |
CSF3R |
1,902 |
409 |
156 |
3,433 |
6,687 |
282 |
0.2 |
2 |
4 |
|
220088_at |
C5AR1 |
56 |
34 |
93 |
2,316 |
5,099 |
3,824 |
41 |
25 |
55 |
|
221698_s_at |
CLEC7A |
3,229 |
4,295 |
79 |
6,642 |
7,061 |
5,680 |
1 |
2 |
2 |
|
204204_at |
SLC31A2 |
442 |
187 |
<50 |
1,579 |
2,047 |
1,671 |
4 |
4 |
5 |
|
|
||||||||||
|
*Average expression across replicates. Mono, monocyte; neu, neutrophil. |
||||||||||
|
Robbins et al. Genome Biology 2008 9:R17 doi:10.1186/gb-2008-9-1-r17 |
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