Figure 1.

ACE1 and ACE1-like gene clusters in filamentous fungi. Colors indicate gene orthology in different species and paralogs in the same species. Horizontal lines indicate genes that are adjacent in the genome, with gene orientations as shown. Genomic regions are not drawn to scale. Parts A and B of the M. grisea cluster as identified in the text are marked. The core set of three genes inferred to have been present in the ancestral cluster are boxed. Vertical lines indicate the closest relatives of genes in the M. grisea cluster and one of the A. clavatus clusters, based on phylogenetic analyses (Figure 2 and Additional data file 1). The species phylogeny is based on the whole-genome supertree analysis of Fitzpatrick et al [27]; in that study the placement of Dothideomycetes relative to Sordariomycetes and Eurotiomycetes varied depending on the method of analysis, so we have shown it as a trichotomy. The analysis of Hane et al of the complete S. nodorum genome placed Dothideomycetes and Sordariomycetes in a clade with Eurotiomycetes outside [47]. Species-specific gene nomenclature is shown, except for M. grisea (Collemare et al, unpublished results). Red, green and blue coloring of species names corresponds to the labelling of individual genes from the clusters in Figure 2 and Additional data file 1.0.