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Biological networks and associated top functions generated from polysome-bound probe sets regulated upon HepaRG cell differentiation |
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| Networks |
Top functions |
Members* |
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| Up-regulated |
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| A |
Cell cycle |
ACTR2, C21ORF33, CAST, CCND3, CD86, CDC34, CKB, DACH1, EDA, FASTK, FKBP5, HDAC5, HSP90B1, MEF2C, MEF2D, NF-KBIA, PHB, PLCL1, PTMS, PTN, PTPN13, RAB5B, RAB5C, SF3B1, SF3B3, SMARCA2, SMARCB1, SMARCC2, TF, TMOD1, TSC22D3, UBE1 |
| B |
Cell death |
ACO1, ACO2, ALB, ATRX, BCAP31, BRAF, CALR, CASP8, CFLAR, FCGRT, FOXA1, FTL, HLA-F, IFI16, IGFBP1, IHPK2, IL6R, KNG1, LRP1, MADD, MAP2K2, MDM2, NBN, NEK1, NOL3, PEBP1, RAD50, SIVA, THBS3, TSC2, TTR, ZNF350 |
| C |
Cell death Innate immunity |
BCL2, BCL2L11, BCLAF1, BNIP3L, BSG, CAPN1, CAPN7, CASP9, CCNG2, DUSP6, FOXO3A, FRAT2, HBP1, IRF3, IRF7, LBP, MAP2, MAPT, MOAP1, NDRG1, NOSIP, PDCD8, PPP2R4, PTBP1, RARRES3, RBM5, SATB1, TEGT, TNFRSF11B, TNFSF10, TNFSF13, WWOX |
| D |
Innate immunity |
BBS4, C3, C1RL, C1S, CDK5, CDK5RAP2, CFB, CFI, DCTN1, DDB2, DHX9, ECM1, ERBB3, HP, IL6ST, MCM4, MCM5, NR3C2, OAS1, PCM1, PIAS1, PIN1, PIP5K1C, PPP1R1A, PTPN6, RASSF4 (includes EG:83937), RNF41, RRAS, SAP18, SERPING1, SP100, STAT1, TLN1 |
| E |
Lipid metabolism Drug metabolism |
ADRA1A, AMPH, AP2A2, APBA3, APOA1, APOC3, BIN1, CEBPD, CPB2, DNM2, EFNA1, EHD1, EPPB9, FABP4, FGA, FGB, FGG, HELZ, HMGCS2, HSD17B4, IL13RA2, MECR, MLYCD, NCKIPSD, NR1H4, PLA2G2A, PLD1, PPARA, SMYD3, SORBS2, STAT3, SYT1, VAMP2, WASL |
| F |
Lipid metabolism Drug metabolism |
ACOX1, ADH6, BRD8, CEBPA, CEP350, CHI3L1, CRADD, CYP3A4, CYP3A5, CYP3A7, FABP1, GADD45G, H1FX, HADHA, HADHB, HPR, MPG, NFIL3, NR1H2, PCBP2, PEX11A, PLOD2, PPARD, RXRA, S100A8, S100A9, SERPINB1, SLC10A1, SMPDL3A, SULT2A1, TANK, UBN1 |
| G |
Lipid metabolism Drug metabolism |
ACAA1, ACACB, ADH1A, ADH1B, ADH1C, ADM, AGT, AMACR, ATP1A1, CFH, DBP, DHCR7, EHHADH, FASN, FDPS, FXYD2, HLF, MEIS1, MLXIPL, MVD, MYH10, NSDHL, PEX5, PEX7, PPP1R12A, PURA, PYGL, RXRB, SREBF1, TCF8, TM7SF2, TXNIP, ZBTB16 |
| H |
Cell morphology |
AIP, ANXA6, ARHGAP1, ARHGEF9, C13ORF24, CBLB, CD40, CDC42, COPA, COPB2, COPE, COPG, COPZ1, CUL5, DOCK9, DPP4, FYN, IQGAP1, JAK2, PDE4A, PIK3R1, PLCG1, PRMT5, PTPRA, SLIT2, SND1, SORBS1, STAT6, TCEB2, TIMP1, USP33 |
| I |
Cell environment |
A2M, APOH, C5, C6, EGR1, ENPEP, F5, F10, FN1, IGFBP2, IL1R1, MAOB, MGP, MMP3, MTCP1, NAB2, NUP88, NUP214, NXF3, ORM1, SAPS2, SERPINA5, SERPINF2, SLC25A4, SOD2, SPARC, SPOCK3, ST6GAL1, TAOK2, TFPI, TFPI2, VPS45A, VTN |
| Down-regulated |
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| J |
Cell movement |
ACACA, BMP2, CCL2, CSF1, DDX21, FHL2, HGF, HNRPL, IL8, IRAK1, ITGA6, ITGAM, LIF, NCF2, PDGFB, POSTN, SERPINE1, SLC12A6, SYK, TGFB2, THBS1, TLR3, TNC, TNFAIP3, TRAF1, VEGF |
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*Members indicative of translational regulation are underlined. Members indicative of transcriptional regulation are not underlined. Members sharing the greatest number of connections within the network are in bold. | ||
Parent and Beretta Genome Biology 2008 9:R19 doi:10.1186/gb-2008-9-1-r19 |
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