Method
High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
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* Corresponding author: Won-Ki Huh wkh@snu.ac.kr
- † Equal contributors
1 Department of Bioinformatics, Dong-a Seetech Research Institute, Seoul 135-010, Republic of Korea
2 School of Biological Sciences and Research Center for Functional Cellulomics, Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea
3 Computational Biology Division, TGEN, N 5th St, Phoenix, Arizona 85004, USA
Genome Biology 2008, 9:R2 doi:10.1186/gb-2008-9-1-r2
Published: 3 January 2008Abstract
We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.