Method

High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae

Hun-Goo Lee^{* 1,2} , Hyo-Soo Lee^{* 1} , Sang-Hoon Jeon¹ , Tae-Hoon Chung³ , Young-Sung Lim¹ and Won-Ki Huh²

¹Department of Bioinformatics, Dong-a Seetech Research Institute, Seoul 135-010, Republic of Korea

²School of Biological Sciences and Research Center for Functional Cellulomics, Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea

³Computational Biology Division, TGEN, N 5th St, Phoenix, Arizona 85004, USA

author email corresponding author email* Contributed equally

Genome Biology 2008, 9:R2doi:10.1186/gb-2008-9-1-r2

Published:	3 January 2008

Subject areas: Genome studies, Methods, Model organisms

Abstract

We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.