Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia coli

Morgan N Price¹^,2 , Paramvir S Dehal¹^,2 and Adam P Arkin¹^,2^,3

¹Physical Biosciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 977-152, Berkeley, California 94720, USA

²Virtual Institute of Microbial Stress and Survival, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 977-152, Berkeley, California 94720, USA

³Department of Bioengineering, 1 Cyclotron Road, Mailstop 977-152, University of California, Berkeley 94720, California, USA

author email corresponding author email

Genome Biology 2008, 9:R4doi:10.1186/gb-2008-9-1-r4


Published:	7 January 2008

Subject areas: Bioinformatics, Evolution, Genome studies, Molecular biology

Additional files

Additional file 1:

Provided is the classification of each TF that we examined, both by evolutionary history and by function.

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Additional data file 2:

The figure plots the sequence conservation of regulators against the number of genes that they regulate.

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Additional data file 3:

The figure illustrates the preference for HGT between related genomes.

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Additional data file 4:

Provided is an evolutionary analysis of 30 cases of shared regulation between homologous genes from the report by Teichmann and Babu [4].

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Additional data file 5:

Provides an evolutionary analysis of each case of shared regulation between 'close' paralogs.

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