Table 1 |
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Cardiopoietic cells demonstrate specific upregulation of genes involved in cardiovascular development |
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|
Gene name |
GenBank ID |
Fold change |
|
|
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|
*Actc |
1.755 |
|
|
*Acvr1 |
2.531 |
|
|
Adam19 |
1.955 |
|
|
Akt1 |
2.518 |
|
|
*Amot |
3.321 |
|
|
Anxa1 |
9.544 |
|
|
Anxa2 |
4.472 |
|
|
Anxa5 |
6.957 |
|
|
*Axl |
16.45 |
|
|
Bmp4 |
1.552 |
|
|
Casp8 |
1.994 |
|
|
Cav1 |
10.81 |
|
|
Cd47 |
2.265 |
|
|
Cd81 |
1.599 |
|
|
Cd151 |
1.597 |
|
|
Cdh2 |
2.861 |
|
|
Col4a2 |
16.98 |
|
|
Ctsb |
4.591 |
|
|
Cyr61 |
6.394 |
|
|
*Ece1 |
2.551 |
|
|
Egfr |
1.641 |
|
|
F3 |
3.146 |
|
|
F2r |
3.117 |
|
|
Fgfr1 |
1.807 |
|
|
Fn1 |
2.536 |
|
|
Furin |
1.858 |
|
|
*Has2 |
2.57 |
|
|
Hif1a |
2.586 |
|
|
Hmox1 |
1.728 |
|
|
Id3 |
1.75 |
|
|
Igf2 |
22.08 |
|
|
Igfbp4 |
10.46 |
|
|
ltga3 |
1.549 |
|
|
ltga5 |
2.908 |
|
|
Itgav |
2.012 |
|
|
Itgb1 |
2.642 |
|
|
Itgb5 |
2.542 |
|
|
Lamc1 |
3.632 |
|
|
Lmna |
4.11 |
|
|
*Ltbr |
5.021 |
|
|
*Mixl1 |
1.647 |
|
|
Mmp2 |
5.483 |
|
|
Mmp14 |
5.742 |
|
|
*Nf1 |
1.542 |
|
|
Nr3c1 |
1.836 |
|
|
Pitx2 |
2.062 |
|
|
*Pou6f1 |
1.647 |
|
|
Ppap2b |
2.42 |
|
|
*Ppp3r1 |
1.704 |
|
|
Reck |
2.305 |
|
|
*Sema3c |
3.763 |
|
|
Serpinf1 |
8.628 |
|
|
*Smo |
1.652 |
|
|
Sparc |
5.953 |
|
|
*Sptbn1 |
1.628 |
|
|
Tgfbr2 |
13.3 |
|
|
Tgm2 |
2.979 |
|
|
Thbs1 |
12.43 |
|
|
Timp1 |
4.251 |
|
|
Timp2 |
40.6 |
|
|
*Tnfrsf12a |
3.322 |
|
|
Tnfrsf1a |
4.763 |
|
|
Vcl |
3.886 |
|
|
Vhl |
1.523 |
|
|
Zfpm1 |
3.272 |
|
|
|
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A total of 65 genes were upregulated with transition from a pluripotent embryonic stem cell into the cardiopoietic phenotype, 49 of which associated as an integrated network (Figure 3a). *Genes without curated interactions. |
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Faustino et al. Genome Biology 2008 9:R6 doi:10.1186/gb-2008-9-1-r6 |
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