Figure 6.

Structure of the Myc/Max transcription factor complex binding DNA [PDB:1NKP]. Both Myc-c and Max form a basic helix-loop-helix motif. They dimerize mainly through their extended helix II regions. The residue that corresponds to Ile156 in H-Twist is Ile550, shown in red. The residue sits at a key position of the interface, forming bonds with seven residues in Max, shown in green.