Review

Large-scale assignment of orthology: back to phylogenetics?

Toni Gabaldón

Bioinformatics and Genomics Program, Center for Genomic Regulation, Doctor Aiguader, 88, 08003 Barcelona, Spain

author email corresponding author email

Genome Biology 2008, 9:235doi:10.1186/gb-2008-9-10-235

Published:	30 October 2008

Subject areas: Evolution, Genome studies

Abstract

Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.