Review
Large-scale assignment of orthology: back to phylogenetics?
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Correspondence: Toni Gabaldón tgabaldon@crg.es
Bioinformatics and Genomics Program, Center for Genomic Regulation, Doctor Aiguader, 88, 08003 Barcelona, Spain
Genome Biology 2008, 9:235 doi:10.1186/gb-2008-9-10-235
Published: 30 October 2008Abstract
Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.