Research
A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection
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* Corresponding author: David Lydall d.a.lydall@ncl.ac.uk
1 Aging Research Laboratories, Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
2 Centre for Integrated Systems Biology of Aging and Nutrition, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
3 School of Mathematics & Statistics, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
4 Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
5 Institute of Human Genetics, International Centre for Life, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK
6 School of Computing Science, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
7 Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Genome Biology 2008, 9:R146 doi:10.1186/gb-2008-9-10-r146
Published: 1 October 2008Additional files
Additional data file 1:
RT-PCR analysis of heat shock gene expression.
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Additional data file 2:
Quality control of microarray strains and samples.
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Additional data file 3:
Table A lists differentially expressed genes in cdc13-1 strains. Tables B-N list genes in QT clusters 1-13, respectively.
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Additional data file 4:
Table A shows GOstats analysis of up-regulated genes. Table B shows GOstats analysis of down-regulated genes. Table C shows GOstats analysis of genes altered in CDC13+ strains. Table D shows GOstats analysis of genes altered in cdc13-1 strains that are not cell cycle regulated. Tables E-Q show GOstats analysis of genes in QT clusters 1-13 respectively.
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Additional data file 5:
Expression of HSP12, MSC1 and CTT1 during the microarray time course.
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Additional data file 6:
Table A lists differentially expressed genes in both cdc13-1 and tlc1Δ. Table B lists genes altered in cdc13-1 but not in tlc1Δ.
Format: XLS Size: 124KB Download file
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Additional data file 7:
Table A lists transcription factor genes up-regulated in cdc13-1 strains. Table B lists transcription factor genes down-regulated in cdc13-1 strains.
Format: XLS Size: 20KB Download file
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