A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection

doi:10.1186/gb-2008-9-10-r146

Genome Biology

Volume 9
Issue 10

Viewing options:

Abstract
Full text
PDF (719KB)
Additional files

Associated material:

PubMed record

Related literature:

Articles citing this article
on Google Scholar
on ISI Web of Science
on PubMed Central
Other articles by authors
on Google Scholar

Greenall A
Lei G
Swan DC
James K
Wang L
Peters H
Wipat A
Wilkinson DJ
Lydall D

on PubMed

Greenall A
Lei G
Swan DC
James K
Wang L
Peters H
Wipat A
Wilkinson DJ
Lydall D
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Research

A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD⁺biosynthetic gene BNA2 in chromosome end protection

Amanda Greenall¹^,2 , Guiyuan Lei²^,3 , Daniel C Swan⁴ , Katherine James²^,5 , Liming Wang⁶ , Heiko Peters⁶ , Anil Wipat²^,5 , Darren J Wilkinson²^,3 and David Lydall¹^,2^,7

¹Aging Research Laboratories, Institute for Aging and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK

²Centre for Integrated Systems Biology of Aging and Nutrition, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK

³School of Mathematics & Statistics, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK

⁴Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK

⁵Institute of Human Genetics, International Centre for Life, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK

⁶School of Computing Science, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK

⁷Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK

author email corresponding author email

Genome Biology 2008, 9:R146doi:10.1186/gb-2008-9-10-r146


Published:	1 October 2008

Subject areas: Biochemistry and structural biology, Cancer, Molecular biology

Additional files

Additional data file 1:

RT-PCR analysis of heat shock gene expression.

Format: PDF Size: 301KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 2:

Quality control of microarray strains and samples.

Format: PDF Size: 1.4MB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 3:

Table A lists differentially expressed genes in cdc13-1 strains. Tables B-N list genes in QT clusters 1-13, respectively.

Format: XLS Size: 138KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 4:

Table A shows GOstats analysis of up-regulated genes. Table B shows GOstats analysis of down-regulated genes. Table C shows GOstats analysis of genes altered in CDC13⁺strains. Table D shows GOstats analysis of genes altered in cdc13-1 strains that are not cell cycle regulated. Tables E-Q show GOstats analysis of genes in QT clusters 1-13 respectively.

Format: XLS Size: 62KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 5:

Expression of HSP12, MSC1 and CTT1 during the microarray time course.

Format: PDF Size: 242KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional data file 6:

Table A lists differentially expressed genes in both cdc13-1 and tlc1Δ. Table B lists genes altered in cdc13-1 but not in tlc1Δ.

Format: XLS Size: 124KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 7:

Table A lists transcription factor genes up-regulated in cdc13-1 strains. Table B lists transcription factor genes down-regulated in cdc13-1 strains.

Format: XLS Size: 20KB Download file

This file can be viewed with: Microsoft Excel Viewer