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Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

Frank Westermann1* email, Daniel Muth1* email, Axel Benner2 email, Tobias Bauer3 email, Kai-Oliver Henrich1 email, André Oberthuer4 email, Benedikt Brors3 email, Tim Beissbarth5 email, Jo Vandesompele6 email, Filip Pattyn6 email, Barbara Hero4 email, Rainer König3 email, Matthias Fischer4 email and Manfred Schwab1 email

Department of Tumor Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

Department of Biostatistics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

Department of Pediatric Oncology, University Children's Hospital of Cologne, Kerpener Strasse 62, Cologne, 50924, Germany

Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany

Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, Ghent, 9000, Belgium

author email corresponding author email* Contributed equally

Genome Biology 2008, 9:R150doi:10.1186/gb-2008-9-10-r150

Published: 13 October 2008

Subject areas: Cancer, Genome studies, Molecular biology


Additional files

Additional data file 1:

Cluster map of genetic programs regulated by conditional expression of c-MYC and MYCN proteins in SH-EPMYCN cells.

Format: PDF Size: 1.1MB Download file

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Additional data file 2:

Detailed methods and materials.

Format: DOC Size: 62KB Download file

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Additional data file 3:

ChIP-chip results of MYCN/c-MYC target genes in the Kelly cell line.

Format: PDF Size: 722KB Download file

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Additional data file 4:

ChIP-chip results of MYCN/c-MYC target genes in the SJ-NB12 cell line.

Format: PDF Size: 687KB Download file

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Additional data file 5:

MYCN/c-MYC target genes, which grouped in class 1 and 2.

Format: XLS Size: 27KB Download file

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Additional data file 6:

MYCN/c-MYC target genes, which grouped in class 4.

Format: XLS Size: 36KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 7:

MYCN/c-MYC target genes, which grouped in class 3.

Format: XLS Size: 34KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional data file 8:

Genes and primers selected to confirm ChIP-chip results.

Format: XLS Size: 37KB Download file

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Additional data file 9:

Association of MYCN/c-MYC induced genes with stage 4s-NA neuroblastomas using the Global test.

Format: PDF Size: 1.1MB Download file

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Additional data file 10:

Association of MYCN/c-MYC induced genes with stage 4-NA neuroblastomas using the Global test.

Format: PDF Size: 1.2MB Download file

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Additional data file 11:

Association of MYCN/c-MYC induced genes with MYCN amplified neuroblastomas using the Global test.

Format: PDF Size: 1.4MB Download file

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Additional data file 12:

Patient data.

Format: XLS Size: 95KB Download file

This file can be viewed with: Microsoft Excel Viewer


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