Research
Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
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* Corresponding author: Frank Westermann f.westermann@dkfz.de
- † Equal contributors
1 Department of Tumor Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
2 Department of Biostatistics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
3 Theoretical Bioinformatics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
4 Department of Pediatric Oncology, University Children's Hospital of Cologne, Kerpener Strasse 62, Cologne, 50924, Germany
5 Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany
6 Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, Ghent, 9000, Belgium
Genome Biology 2008, 9:R150 doi:10.1186/gb-2008-9-10-r150
Published: 13 October 2008Additional files
Additional data file 1:
Cluster map of genetic programs regulated by conditional expression of c-MYC and MYCN proteins in SH-EPMYCN cells.
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Additional data file 2:
Detailed methods and materials.
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Additional data file 3:
ChIP-chip results of MYCN/c-MYC target genes in the Kelly cell line.
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Additional data file 4:
ChIP-chip results of MYCN/c-MYC target genes in the SJ-NB12 cell line.
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Additional data file 5:
MYCN/c-MYC target genes, which grouped in class 1 and 2.
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Additional data file 6:
MYCN/c-MYC target genes, which grouped in class 4.
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Additional data file 7:
MYCN/c-MYC target genes, which grouped in class 3.
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Additional data file 8:
Genes and primers selected to confirm ChIP-chip results.
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Additional data file 9:
Association of MYCN/c-MYC induced genes with stage 4s-NA neuroblastomas using the Global test.
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Additional data file 10:
Association of MYCN/c-MYC induced genes with stage 4-NA neuroblastomas using the Global test.
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Additional data file 11:
Association of MYCN/c-MYC induced genes with MYCN amplified neuroblastomas using the Global test.
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Additional data file 12:
Patient data.
Format: XLS Size: 95KB Download file
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