Table 2

Association of MYCN/c-MYC target gene clusters with overall survival in primary neuroblastomas (n = 251)

Cluster

Number of genes

Rank OS*

p-value OS^†

Rank OS with CV*

p-value OS with CV^†

168 (I)

19

3

<0.0001

1

0.0004

140 (I)

38

4

<0.0001

2

0.0006

195 (I)

21

31

<0.0001

12

0.0060

308 (II)

33

18

<0.0001

26

0.0161

280 (II)

32

29

<0.0001

37

0.0232

336 (II)

26

51

<0.0001

45

0.0280

*Rank of all 504 clusters tested for association with overall survival (OS) using the Global test without and with adjustment for co-variables (CV; amplified MYCN, stages 1, 2, 3, 4s versus 4, age at diagnosis ≥1.5 years). ^†p-value from Global test adjusted for multiple testing. In the Cluster column, I or II gives the cluster group as defined by the SOM analysis using SH-EP^MYCN cells.

Westermann et al. Genome Biology 2008 9:R150   doi:10.1186/gb-2008-9-10-r150