Table 4

Enrichment analysis of protein classes following hierarchical clustering

Node number

Correlation

Proteins in this node

Protein class

Class total

Percent class enrichment

Solid tissue

265

0.98

5

Helicase

3

67

277

0.98

8

Hormone synthesis

4

50

376

0.94

79

Transcription

3

100

376

0.94

79

Chromatin-associated protein

3

67

376

0.94

79

tRNA synthetase

3

67

376

0.94

79

Pentose phosphate pathway

4

50

376

0.94

79

Ubiquitylation

4

50

377

0.94

5

Food

6

50

411

0.90

108

Aldo-keto reductase superfamily

3

67

419

0.89

137

Proteasome

24

67

419

0.89

137

Antioxidant

16

50

419

0.89

137

Protein receptor

4

50

421

0.89

29

ATP synthase

10

60

427

0.88

34

Small molecule receptor

4

50

434

0.86

51

Energy storage

5

80

434

0.86

51

Beta-oxidation

8

50

438

0.83

7

Cuticle

7

57

439

0.83

146

Ras superfamily

10

50

Hemolymph

128

0.97

35

Translation

7

57

150

0.96

6

Short-chain dehydrogenase family

4

50

180

0.93

21

Small molecule receptor

4

50

183

0.92

23

Food

8

63

183

0.92

23

Glycolipid metabolism

3

67

185

0.92

9

Ubiquitylation

4

50

190

0.89

63

Amino acid metabolism

8

50

197

0.86

29

Energy storage

4

100

200

0.84

81

Proteasome

10

90

200

0.84

81

Protein folding

20

60

200

0.84

81

Ribosome

31

81

203

0.82

21

Tricarboxylic acid cycle

4

75

Proteins that were manually categorized by function were subjected to average-linkage clustering (Figure 3). Separate analyses were done for solid tissue and hemolymph. Only proteins that were quantified for at least 4 out of 5 days and protein classes that had at least 5 members were considered for enrichment analysis. Classes with at least 50% enrichment in nodes with a correlation of >0.8 are considered significant and shown.

Chan and Foster Genome Biology 2008 9:R156   doi:10.1186/gb-2008-9-10-r156