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Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis

Robert P Zinzen and Eileen EM Furlong*

Author Affiliations

European Molecular Biology Laboratory, D-69117 Heidelberg, Germany

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Genome Biology 2008, 9:240  doi:10.1186/gb-2008-9-11-240

Published: 4 November 2008

Abstract

Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.