Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis
European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
Genome Biology 2008, 9:240 doi:10.1186/gb-2008-9-11-240Published: 4 November 2008
Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.