Research
Proteomics studies confirm the presence of alternative protein isoforms on a large scale
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* Corresponding author: Michael L Tress mtress@cnio.es
1 Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), C. Melchor Fernandez Almagro, Madrid 28029, Spain
2 Institute of Molecular Systems Biology, ETH, Wolfgang-Pauli-Str., 8093 Zurich, Switzerland
3 Institute for Systems Biology, Seattle, WA 98103, USA
4 Competence Center for Systems Physiology and Metabolic Diseases, ETH Zurich, 8093 Zurich, Switzerland
5 Faculty of Science, University of Zurich, 8057 Zurich, Switzerland
Genome Biology 2008, 9:R162 doi:10.1186/gb-2008-9-11-r162
Published: 18 November 2008Additional files
Additional data file 1:
A list of all alternative isoforms confirmed by the Brunner and Bodenmiller analyses.
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Additional data file 2:
Part 1A shows the phosphopeptide GFGMSHS*LPSGMSR, which is unique to the Sex lethal isoforms CG18350-PD, CG18350-PL, CG18350-PI. Part 1B shows the phosphopeptide GFGMS*HSLPSGMDTEFSFPSSSSR, which is unique to the Sex lethal isoforms CG18350-PG, CG18350-PH, CG18350-PO, CG18350-PC, CG18350-PJ, CG18350-PN. P is the Peptide Prophet score and corresponds to a <1% false positive rate. In addition, all fragment ion masses are shown and detected ions are highlighted in red.
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Additional data file 3:
Fragment ion masses for the phosphopeptide GFGMSHS*LPSGMSR, which is unique to the Sex lethal isoforms CG18350-PD, CG18350-PL, CG18350-PI, are shown in tabular form. Detected ions are highlighted in red.
Format: PDF Size: 34KB Download file
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Additional data file 4:
Fragment ion masses for the phosphopeptide GFGMS*HSLPSGMDTEFSFPSSSSR, which is unique to the Sex lethal isoforms CG18350-PG, CG18350-PH, CG18350-PO, CG18350-PC, CG18350-PJ, CG18350-PN, are shown in tabular form. Detected ions are highlighted in red.
Format: PDF Size: 11KB Download file
This file can be viewed with: Adobe Acrobat Reader