Genome Biology

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Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip

Shilpi Arora, Yipeng Wang, Zhenyu Jia, Saynur Vardar-Sengul, Ayla Munawar, Kutbuddin S Doctor, Michael Birrer, Michael McClelland, Eileen Adamson and Dan Mercola*

Genome Biology 2008, 9:R166 doi:10.1186/gb-2008-9-11-r166

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GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes

Florian Bonin, Manuella Molina, Claude Malet, Chantal Ginestet, Odile Berthier-Vergnes, Michèle T Martin, Jérôme Lamartine BMC Genomics 2009, 10:417 (7 September 2009)

Low-dose irradiation of human keratinocytes induces binding of the transcription factor GATA3 to promoters of low-dose radiation response genes, while knockdown of GATA3 leads to generalized transcriptional deregulation following exposure, and also reduced cell survival.

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Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

David O Azorsa, Irma M Gonzales, Gargi D Basu, Ashish Choudhary, Shilpi Arora, Kristen M Bisanz, Jeffrey A Kiefer, Meredith C Henderson, Jeffrey M Trent, Daniel D Von Hoff, Spyro Mousses Journal of Translational Medicine 2009, 7:43 (11 June 2009)

Research   Open Access

Genome-wide investigation of in vivo EGR-1 binding sites in monocytic differentiation

Atsutaka Kubosaki, Yasuhiro Tomaru, Michihira Tagami, Erik Arner, Hisashi Miura, Takahiro Suzuki, Masanori Suzuki, Harukazu Suzuki, Yoshihide Hayashizaki Genome Biology 2009, 10:R41 (19 April 2009)

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A Genome-wide analysis of EGR-1 binding sites reveals co-localization with CpG islands and histone H3 lysine 9 binding. SP-1 binding occupancies near EGR-1 binding sites are dramatically altered.