Lymphatic endothelial differentiation: start out with Sox - carry on with Prox

doi:10.1186/gb-2008-9-12-243

Genome Biology

Volume 9
Issue 12

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Lymphatic endothelial differentiation: start out with Sox - carry on with Prox

Friedemann Kiefer¹ and Ralf H Adams²^,3

¹Max-Planck-Institute for Molecular Biomedicine, Department of Vascular Cell Biology, D-48149 Münster, Germany

²Max-Planck-Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, D-48149 Münster, Germany

³University of Münster, Faculty of Medicine, D-48149 Münster, Germany

author email corresponding author email

Genome Biology 2008, 9:243doi:10.1186/gb-2008-9-12-243


Published:	29 December 2008

Subject areas: Cell biology, Development, Genetics, Physiology

Abstract

The transcription factor Prox1 is the master regulator of lymphatic endothelial cell differentiation and its expression initiates the morphogenesis of the lymphatic vasculature in the early embryo. Two new studies now answer some fundamental questions concerning Prox1 biology.