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Replication forks, chromatin loops and dormant replication origins

J Julian Blow* and Xin Quan Ge

Author Affiliations

Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK

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Genome Biology 2008, 9:244  doi:10.1186/gb-2008-9-12-244

Published: 30 December 2008

Abstract

When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.