Research
Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells
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* Corresponding authors: Stylianos E Antonarakis stylianos.antonarakis@medecine.unige.ch - John A Stamatoyannopoulos jstam@stamlab.org
1 Department of Genetic Medicine and Development, University of Geneva Medical School, 1 rue Michel Servet, 1211, Geneva 4, Switzerland
2 Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland
3 Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, USA
4 Department of Medical Genetics, Ullevål University Hospital, 0407 Oslo, Norway
5 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
6 Current address: Genomics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Genome Biology 2008, 9:R168 doi:10.1186/gb-2008-9-12-r168
Published: 2 December 2008Additional files
Additional data file 1:
Vectors used in enhancer and promoter studies.
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Additional data file 2:
Table S1: regulatory potential of CNCSs based on published work. Table S2: direct DNAseI hypersensitivity testing of random CNCSs: (a) CNCS-DHSs by tissue type; (b) all 192 randomly-selected CNCSs tested for DNAseI hypersensitivity across cell types. Table S3: unbiased mapping of DNAseI hypersensitive sites across 2.2 Mb of Chr21; coordinates of DNAseI hypersensitive sites by tissue. Table S4: coordinates of CNCSs and controls for cell transfection assays.
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