Use of differentially and constantly expressed genes to rediscover disease genes. The DER was calculated as the count of GEO datasets in which a gene was differentially expressed divided by the count of GEO datasets in which it was measured. For any cutoff x, differentially expressed genes were defined as genes with DER > x, whereas constantly expressed genes were defined as genes with DER <x. The precision/recall graphs show that the likelihood of harboring disease mutations for a gene increases when its DER value increases. For the control, we shuffled disease labels 10,000 times among all genes and obtained a predicted precision of 16%. DER, differential expression ratio; GEO, Gene Expression Omnibus.
Chen et al. Genome Biology 2008 9:R170 doi:10.1186/gb-2008-9-12-r170