Distinguishing T1DM genes from false positives in the top seven loci from GWASs using DER. Genes in the top seven loci from the WTCCC T1DM GWASs are reported with validation results. False-positive genes were shown as positive in the initial scan but found to be unassociated with T1DM in the follow-up validation studies. T1DM genes had significantly higher DER values than did false positive genes (P = 0.003). The mean DER values for T1DM and false-positive genes were 0.59 and 0.50, respectively. DER, differential expression ratio; GWAS, genome-wide association study; T1DM, type 1 diabetes mellitus; WTCCC, Wellcome Trust Case Control Consortium.
Chen et al. Genome Biology 2008 9:R170 doi:10.1186/gb-2008-9-12-r170