Prediction that OBSL1 is associated with systemic lupus erythematosus with nephritis through 2q34-q35. Systemic lupus erythemetosus with nephritis (SLEN2; OMIM %607966) was identified to be associated with 2q34-q35 but without identification of specific genes. OBSL1 has a much higher DER value (0.71) than those of all other genes from 2q34-q35. It was also found to be differentially expressed in juvenile idiopathic arthritis, kidney cancer, and kidney transplant rejection. Therefore, we suggest that it should be sequenced for its potential association with SLEN2.
Chen et al. Genome Biology 2008 9:R170 doi:10.1186/gb-2008-9-12-r170