Research
Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences
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* Corresponding author: Laurence Ettwiller ettwille@embl.de
1 Developmental Biology Unit, EMBL-Heidelberg, Meyerhofstraße 1, Heidelberg, 69117, Germany
2 Structural and Computational Biology Unit, EMBL-Heidelberg, Meyerhofstraße 1, Heidelberg, 69117, Germany
3 Current address: Heidelberg Institute of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, Heidelberg, 69120, Germany
4 Current address: Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Hermann-von-Helmholtz-Platz 1, Karlsruhe, 76021, Germany
Genome Biology 2008, 9:R172 doi:10.1186/gb-2008-9-12-r172
Published: 16 December 2008Additional files
Additional data file 1:
Summary of the ChIP data used.
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Additional data file 2:
Over-represented motifs.
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Additional data file 3:
Over-represented motifs.
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Additional data file 4:
Numerical values from Figure 1a,b as well as the genes analyzed and their orthologues in the 25 species studied.
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Additional data file 5:
De novo analysis of over-represented motifs in the orthologous regions of the E2F1/E2F4 bound locus in human.
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Additional data file 6:
Positional bias of the binding sites relative to the TSS.
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Additional data file 7:
Detailed analysis of the ancestral core.
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Additional data file 8:
Composition of the ancestral core and the position frequency matrices used to find the cores.
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Additional data file 9:
Transcription factors with conserved DNA-base residues.
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Additional data file 10:
Distribution of motif number in core and non-core genes.
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Additional data file 11:
Supplementary notes.
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