Figure 1.

Genes in S. cerevisiae are classified into four groups according to their lethality and the lethality of protein complexes to which they belong. Within each group, the pie chart represents the distribution of genes with respect to the lethality of their orthologs in C. elegans. (a) The lethal protein complexes were identified using the HG enrichment test (p-value < 0.05). (b) 'Overlapping protein complexes' (the probability of being lethal inferred by the BN model < 0.7) were filtered out from those identified in (a).